Media
Stars in Global Health: Stephanie Yanow
Revamping an old tool: point-of-care molecular diagnostics in blood capillary tubes
Transforming the classic blood capillary tube into a diagnostic device that integrates whole blood collection with molecular testing. Capillaries are fabricated with 'hydrogel', an acrylamide gel that includes reagents for detection of malaria and other infections. The device will provide novel diagnostics at point-of-care.
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Biography
Dr. Stephanie Yanow is an Associate Professor in Global Health at the School of Public Health at the University of Alberta. Her research program is focused on different aspects of malaria from basic pathogenesis to translational development of diagnostics and vaccines. Her lab is engaged in a multidisciplinary collaboration to transfer molecular diagnostic tests for malaria to a platform to be used at the point-of-care in limited-resource areas. Yanow has partnered with international colleagues to pilot this technology in malaria-endemic settings (Uganda, India). Another major focus of her lab work is on the interactions between malaria parasites of different species and the host immune response, particularly during infection in pregnancy. From her work with colleagues in Colombia and Brazil, she, along with her colleagues, discovered that exposure to Plasmodium vivax may induce protective antibodies against P. falciparum in pregnancy, leading to improved birth outcomes. She is currently trying to understand this mechanism of cross-species immunity and exploit these findings for vaccine development.