Emerging Picture on Role of EDCs, Microbiome in Obesity, Diabetes
Medscape, December 18, 2015Online
Dr Kurrasch went on to describe the knowledge base to date on the more than 100 known endocrine-disrupting chemicals, which are believed to interfere with hormone systems, either by mimicking hormones or blocking normal hormonal signaling ...
5 Ways To Store Food Without Plastic
Huffington Post, February 24, 2016Online
The problem, as outlined by the study, is that "[a] lot of the alternative chemicals have not been adequately tested because they don't have to be," said lead author Deborah Kurrasch ...
Shox2 is required for the proper development of the facial motor nucleus and the establishment of the facial nerves
Published by BMC Neuroscience
2015 Axons from the visceral motor neurons (vMNs) project from nuclei in the hindbrain to innervate autonomic ganglia and branchial arch-derived muscles. Although much is known about the events that govern specification of somatic motor neurons, the genetic pathways responsible for the development of vMNs are less well characterized.
Protocadherins and Hypothalamic Development: Do They Play An Unappreciated Role?
Published by Journal of Neuroendocrinology
2015 Normal brain development requires coordinated cell movements at precise times. It has long been established that cell–cell adhesion proteins of the cadherin superfamily are involved in the adhesion and sorting of cells during tissue morphogenesis. In the present review, we focus on protocadherins, which form the largest subfamily of the cadherin superfamily and mediate homophilic cell–cell adhesion in the developing brain.
Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish
Published by Proceedings of the National Academy of Science USA
2015 Here we demonstrate that bisphenol A (BPA) exposure during a time point analogous to the second trimester in humans has real and measurable effects on brain development and behavior. Furthermore, our study is the first, to our knowledge, to show that bisphenol S, a replacement used in BPA-free products, equally affects neurodevelopment.
Mice lacking the transcription factor SHOX2 display impaired cerebellar development and deficits in motor coordination
Published by Developmental Biology
2015 Purkinje cells of the developing cerebellum secrete the morphogen sonic hedgehog (SHH), which is required to maintain the proliferative state of granule cell precursors (GCPs) prior to their differentiation and migration to form the internal granule layer (IGL). Despite a wealth of knowledge regarding the function of SHH during cerebellar development, the upstream regulators of Shh expression during this process remain largely unknown. Here we report that the murine short stature homeobox 2 (Shox2) gene is required for normal Shh expression in dorsal-residing Purkinje cells.
Adverse morphological development in embryonic zebrafish exposed to environmental concentrations of contaminants individually and in mixture
Published by Aquatic Toxicology
2016 Exposure to environmental contaminants has been linked to developmental and reproductive abnormalities leading to infertility, spontaneous abortion, reduced number of offspring, and metabolic disorders.
Deborah M. Kurrasch is an Associate Professor in the Department of Medical Genetics at the University of Calgary and a Scientist at the Alberta Children’s Hospital Research Institute. Kurrasch’s research is focused neural development, using both mice and zebrafish as model organisms. The Kurrasch laboratory is particularly interested in how chemicals in our environment might be affecting normal brain development in utero. Her lab has shown that the exposure to the plasticizer bisphenol A (BPA) and its replacement BPS causes more neurons to be born at the wrong time, thereby potentially leading to inappropriate circuitry formations that may lead to problems later in life such as ADHD. Kurrasch's lab is currently exploring potential agents that may block the effects of these chemicals during pregnancy and also is now collaborating with clinicians to translate her work into humans. In addition, her lab has also developed a novel drug screening platform that uses zebrafish seeks to uncover therapies for a variety of CNS disorders. Their lead compound is now starting clinical trials for epilepsy and she is now pivoting her platform to other clinically resistant disorders such as autism. Her work is funded by the Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada, among other private foundations, and she currently is the Lead PI on a large, multi-center grant funded by Brain Canada. Kurrasch received her PhD in Molecular Pharmacology from Purdue University and conducted two postdoctoral fellowships, one at the University of Texas – Southwestern Medical Center in Dallas and one at the University of California – San Francisco. Kurrasch has received various awards for her scholarly work, and was recently selected to Calgary’s Top 40 Under 40 (2012).
Calgary’s Top 40 Under 40 | Professional
2012 "They are our educators, innovators and entrepreneurs. They rule the C-suite and both the corporate and volunteer boardrooms. Whether in the arts, non-profits, oil and gas, law, finance or medicine, they are doing more and doing it better and faster."
Additional Titles and Affiliations
CEO and Co-Founder : Path Therapeutics Inc.
The role of microglia in hypothalamic development
Satellite Symposium on Forebrain Development, Canadian Developmental Biology Meeting
Banff, AB, March 16, 2016
Hormone control of neural progenitors during embryonic brain development, and interference by EDCs
Gordon Research Conference on Environmental Endocrine Disruptors
Sunday River, Maine, June 19, 2016
Development of non-neuronal cells critical for central control of obesity
2016 Obesity Summit
London, UK, April 12, 2016
Bisphenol A and its replacement BPS induce precocious neurogenesis and hyperactivity in zebrafish
The International Chemical Congress of Pacific Basin Societies
Honolulu, Hawaii, December 15, 2015
A zebrafish-based platform to uncover drugs that restore mitochondrial function
Zebrafish for Personalized Medicine Conference
Toronto, ON, September 23, 2015
Platform Support GrantOrganization: Brain Canada
Date: January 1, 2016
Grant amount: 2953370
2015-2018 "High-impact research in neuroscience and mental health has always required skill, imagination, determination and insight, and nowadays it also requires access to shared equipment, facilities, services, databases, computing and informatics facilities, patient repositories, and biobanks, collectively referred to as technology 'platforms'."
More information: http://braincanada.ca/en/platform_support_grants
Research GrantOrganization: Canadian Institutes of Health Research
Date: January 1, 2012
Grant amount: 615000
2012-2017 For Molecular Mechanisms Governing Hypothalamic Development and Disease.
More information: http://www.cihr-irsc.gc.ca/e/37788.html
Discovery GrantOrganization: NSERC
Date: January 1, 2016
Grant amount: 165000
2016-2021 The Discovery Grants Program supports ongoing programs of research (with long-term goals) rather than a single short-term project or collection of projects.
Discovery GrantOrganization: NSERC
Date: January 1, 2010
Grant amount: 135000
2010-2015 For Regulation of Neuropeptidergic Cell Homeostasis.
Eyes High Postdoctoral Fellowship CompetitionOrganization: University of Calgary
Date: January 1, 2014
Grant amount: 110000
Program to recruit top-tier postdoctoral fellows, 50 awarded/200 applicants.
More information: http://www.ucalgary.ca/research/eyes-high-postdoc