Helping journalists, producers and conference planners find the female guests, speakers and expert sources they need.

Juliet Daniel

Professor of Biology, McMaster University

Dr. Daniel is a Cancer Biologist with expertise in breast cancer, racial disparities in cancer, and diversity issues in higher education.

Media

ZBTB33 (Mus musculus).

Published by Transcription Factor Encyclopedia

Nanan KK and Daniel JM.  ZBTB33 (Mus musculus).  (2010) Transcription Factor Encyclopedia. 13 (3)

URL: http://www.cisreg.ca/cgi-bin/tfe/articles.pl?tfid=944

Tyrosine phosphorylation and cadherin/catenin function.

Published by Bioessays

Daniel JM and Reynolds AB. Tyrosine phosphorylation and cadherin/catenin function. (1997) Bioessays 19: 883-891.

The p120ctn-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides.

Published by Nucleic Acid Research

Daniel JM, Spring CM, Reynolds AB, Crawford HC and Baig A. The p120ctn-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides. (2002) Nucleic Acids Res. 30: 2911-2919.

The POZ‐ZF transcription factor Kaiso (ZBTB33) induces inflammation and progenitor cell differentiation in the murine intestine.

Published by PLoS ONE

Chaudhary R, Pierre CC, Nanan K, Wojtal D*, Morone S, Pinelli C, Wood GM, Robine S and Daniel JM. The POZ‐ZF transcription factor Kaiso (ZBTB33) induces inflammation and progenitor cell differentiation in the murine intestine. (2013) PLoS ONE 8(9): e74160.

The tyrosine kinase substrate p120cas binds directly to E-cadherin but not APC or α-catenin

Published by Journal of Molecular Cell Biology

Daniel JM and Reynolds AB. The tyrosine kinase substrate p120cas binds directly to E-cadherin but not APC or α-catenin. (1995) Mol. Cell. Biol. 15: 4819-4824.

The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns)

Published by Genomics

Reynolds AB, Jenkins NA, Gilbert DJ, Copeland NG, Shapiro DN, Wu J and Daniel JM. The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns). (1996) Genomics 31: 127-129.

The human enhancer-blocker CTCF interacts with the transcription factor Kaiso.

Published by Journal Biology Chemistry

Defossez PA, Kelly KF, Filion G, Magdinier F, Menoni H, Nordgaard CL, Daniel JM and Gilson E. The human enhancer-blocker CTCF interacts with the transcription factor Kaiso. (2005) J. Biol. Chem. 280:43017-43023.

The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH 3T3 fibroblasts

Published by Experimental Cell Research

Reynolds AB, Zhang Z, Wu J, Daniel JM and Mo Y-Y. The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH 3T3 fibroblasts. (1996) Exp. Cell Res. 225: 328-337.

The catenin p120ctn inhibits Kaiso-mediated Transcriptional Repression of the β-catenin/TCF target gene matrilysin

Published by Experimental Cell Research

Spring CM, Kelly KF, O’Kelly I, Graham M, Crawford HC and Daniel JM. The catenin p120ctn inhibits Kaiso-mediated Transcriptional Repression of the β-catenin/TCF target gene matrilysin. (2005) Exp. Cell Res. 305:253- 265.

The catenin p120ctn interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor

Published by Journal of Molecular Biology

Daniel JM and Reynolds AB. The catenin p120ctn interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. (1999) Mol. Cell. Biol. 19: 3614-3623.

Selective uncoupling of p120ctn from E-cadherin disrupts strong adhesion.

Published by Journal of Cell Biology

Thoreson MA, Anastasiadis PZ, Daniel JM, Ireton RC, Wheelock MJ, Johnson KR, Hummingbird DK and Reynolds AB. Selective uncoupling of p120ctn from E-cadherin disrupts strong adhesion. (2000) J. Cell Biol. 148: 189-201.

Regulation of the Rapsyn promoter by Kaiso and δ-catenin.

Published by Journal of Molecular Cell Biology

Rodova M, Kelly KF, VanSaun M, Daniel JM and Werle MJ. Regulation of the Rapsyn promoter by Kaiso and δ-catenin. (2004) Mol. Cell. Biol. 24: 7188-7196.

POZ for Effect – POZ-ZF Transcription Factors in Cancer and Development

Published by Trends Cell Biology

Kelly KF and Daniel JM. POZ for Effect – POZ-ZF Transcription Factors in Cancer and Development. (2006) Trends Cell Biol. 16: 578-587.

Production and characterization of monoclonal antibodies to ARVCF

Published by Hybridoma

Mariner DJ, Sirotkin H, Daniel JM, Lindman BR, Mernaugh RL, Patten AK, Thoreson MA, Kucherlapati R and Reynolds AB. Production and characterization of monoclonal antibodies to ARVCF. (1999) Hybridoma 18: 343-349.

NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression.

Published by Journal of Cell Science

Kelly KF, Spring CM, Otchere AA and Daniel JM. NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression. (2004) J. Cell Sci. 117: 2675-2686.

Non-Canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin

Published by Nature Cell Biology

Kim SW, Park JI, Spring CM, Sater AK, Ji H, Otchere AA, Daniel JM and McCrea PD. Non-Canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin. (2004) Nat. Cell Biol. 6: 1212-1220.

Nuclear Import of the BTB/POZ Transcriptional Regulator Kaiso.

Published by Journal of Cell Science

Kelly KF, Otchere AA, Graham M and Daniel JM. Nuclear Import of the BTB/POZ Transcriptional Regulator Kaiso. (2004) J. Cell Sci. 117: 6143-6152.

Nuclear Kaiso Expression is associated with High Grade and Triple-Negative Invasive Breast Cancer.

Published by PLoS ONE

Vermeulen JF, van de Ven RAH, Ercan C, van der Groep P, van der Wall E, Bult P, Christgen M, Lehmann U, Daniel JM, van Diest PJ and Derksen PWB. Nuclear Kaiso Expression is associated with High Grade and Triple-Negative Invasive Breast Cancer. (2012) PLoS ONE 7(5): e37864.

Nuclear trafficking of the novel POZ-ZF protein Znf131.

Published by Molecular Cell Research

Donaldson NS, Daniel Y*, Kelly KF, Graham M and Daniel JM. Nuclear trafficking of the novel POZ-ZF protein Znf131. (2007) BBA- Mol. Cell Res.1773: 546-555.

Methylation-dependent regulation of hypoxia inducible factor-1 alpha gene expression by the transcription factor Kaiso.

Published by BBA- Gene Regulatory Mechanisms

Pierre CC, Longo J*, Hallett RM, Milosavljevic S, Bassey BI, Beatty L*, Hassell JA and Daniel JM. Methylation-dependent regulation of hypoxia inducible factor-1 alpha gene expression by the transcription factor Kaiso. (2015) BBA- Gene Regulatory Mechanisms 1849(12):1432-1441

Monoclonal antibodies to Kaiso, a novel transcription factor and p120ctn-binding protein.

Published by Hybridoma

Daniel JM, Ireton RC and Reynolds AB. Monoclonal antibodies to Kaiso, a novel transcription factor and p120ctn-binding protein. (2001) Hybridoma 20: 159-166.

Isolation and characterization of XKaiso, a transcriptional repressor that associates with the catenin Xp120ctn in Xenopus laevis

Published by Journal of Biological Chemistry

Kim SW, Fang X, Ji L, Paulson AF, Daniel JM, Ciesiolka M, van Roy F and McCrea PD. Isolation and characterization of XKaiso, a transcriptional repressor that associates with the catenin Xp120ctn in Xenopus laevis. (2002) J. Biol. Chem. 277: 8202-8208.

Isolation of two novel ras genes in Dictyostelium discoideum; evidence for a complex, developmentally regulated ras gene subfamily.

Published by Oncogene

Daniel J, Bush J, Cardelli J, Spiegelman GB and Weeks G. Isolation of two novel ras genes in Dictyostelium discoideum; evidence for a complex, developmentally regulated ras gene subfamily. (1994) Oncogene 9: 501-508.

Kaiso depletion attenuates transforming growth factor-β signaling and metastatic activity of triple negative breast cancer cells.

Published by Oncogenesis

March 21, 2016

Bassey-Archibong BI, Kwacien JM, Milosavljevic S, Hallett RM, Rayner LGA, Erb MJ, Crawford-Brown CJ*, Stephenson KB, Bedard P-A, Hassell JA and Daniel JM. Kaiso depletion attenuates transforming growth factor-β signaling and metastatic activity of triple negative breast cancer cells. (2016) NPG-Oncogenesis 5, e208 Published online 21st March 2016

Kaiso overexpression promotes intestinal inflammation and potentiates intestinal tumorigenesis in ApcMin/+ mice

Published by BBA- Molecular Basis of Disease

Pierre CC, Longo J*, Mavor M*, Milosavljevic S, Chaudhary R, Gilbreath E, Yates C and Daniel JM. Kaiso overexpression promotes intestinal inflammation and potentiates intestinal tumorigenesis in ApcMin/+ mice (2015) BBA- Molecular Basis of Disease 1842(9): 1846-1855

Kaiso regulates Znf131-mediated transcriptional activation.

Published by Experimental Cell Research

Donaldson NS, Nordgaard CL, Pierre CC, Kelly KF, Robinson S, Swystun L*, Henriquez R*, Graham M and Daniel JM. Kaiso regulates Znf131-mediated transcriptional activation. (2010) Exp. Cell Res. 316: 1692-1705.

Kaiso represses the cell cycle gene cyclin D1 via sequence-specific and methyl-CpG-dependent mechanisms.

Published by PLoS ONE

Donaldson NS, Pierre CC, Anstey MI, Robinson SC, Weerawardane S and Daniel JM. Kaiso represses the cell cycle gene cyclin D1 via sequence-specific and methyl-CpG-dependent mechanisms. (2012) PLoS ONE 7(11): e50398.

Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression.

Published by Oncotarget

Wang H, Liu W, Black S, Turner O, Daniel JM, Dean-Colomb W, He QP, Davis M and Yates C. 
Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression. (2016) Oncotarget, 7(5): 5677-5689

Hypoxia inducible factor (HIF)-2α is required for the development of the catecholaminergic phenotype of sympathoadrenal cells.

Published by Journal of Neurochemistry

Brown ST, Kelly KF, Daniel JM and Nurse CA. Hypoxia inducible factor (HIF)-2α is required for the development of the catecholaminergic phenotype of sympathoadrenal cells. (2009) J. Neurochem. 110: 622-630.

Identification of a new catenin: The tyrosine kinase substrate p120cas associates with E-cadherin complexes

Published by Journal of Molecular Cell Biology

Reynolds AB, Daniel J, McCrea PD, Wheelock MT, Wu J and Zhang Z. Identification of a new catenin: The tyrosine kinase substrate p120cas associates with E-cadherin complexes. (1994) Mol. Cell. Biol. 14: 8333-8342.

Dancing in and out of the nucleus: p120ctn and the transcription factor Kaiso. (2007) BBA- Molecular Cell Research Special issue “The p120-Catenin Protein Family”

Published by Molecular Cell Research Special Issue

Daniel JM. Dancing in and out of the nucleus: p120ctn and the transcription factor Kaiso. (2007) BBA- Molecular Cell Research Special issue “The p120-Catenin Protein Family”. 1773: 59-68. (Guest Co-editor with Dr. Alpha Yap).

Characterization of a third ras gene, rasB, that is expressed throughout the growth and development of Dictyostelium discoideum.

Published by Oncogene

Daniel J, Spiegelman GB and Weeks G. Characterization of a third ras gene, rasB, that is expressed throughout the growth and development of Dictyostelium discoideum. (1993) Oncogene 8: 1041-1047.

Cloning and characterization of 5 novel Dictyostelium discoideum rab-related genes.

Published by Gene

Bush J, Franek K, Daniel J, Spiegelman GB, Weeks G and Cardelli J. Cloning and characterization of 5 novel Dictyostelium discoideum rab-related genes. (1993) Gene 136: 55-60.

A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus

Published by The Journal of Biological Chemistry

erber EC, Kajita M, Wadlow A, Tobiansky L, Niessen C, Ariga H, Daniel J, Fujita Y. A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus. (2008) J. Biol. Chem. 283:12691-12700.

A Dictyostelium morphogen that is essential for stalk cell formation is generated by a subpopulation of pre-stalk cells

Published by Development

Kwong L, Xie Y, Daniel J, Robbins SM and Weeks G. A Dictyostelium morphogen that is essential for stalk cell formation is generated by a subpopulation of pre-stalk cells. (1990) Development 110: 303-310.

Biography

Dr. Juliet Daniel is a Professor in the Department of Biology at McMaster University. Dr. Daniel received her B.Sc. from Queen’s University (Kingston), her Ph.D. from UBC (Vancouver) and completed postdoctoral fellowships at St. Jude Children’s Research Hospital and Vanderbilt University in Tennessee. At McMaster, Dr. Daniel’s research team focuses on understanding how disruptions in cell-cell adhesion and signaling contribute to cancer initiation and progression. Dr. Daniel is most interested in the aggressive triple negative breast cancer (TNBC) subtype that is associated with poor prognosis due to an absence of specific therapies. Intriguingly, young pre-menopausal women of African ancestry have a higher TNBC prevalence and mortality compared to other ethnicities despite a lower incidence and lifetime risk of breast cancer. Since socio-economic status does not fully explain the racial disparity in TNBC prevalence and mortality, Dr. Daniel's research team seeks to identify unique biomarkers or gene mutations that may explain this racial disparity. Her team will utilize genetic, genomic, molecular and cell biology techniques to analyze TNBC tissues from populations of shared African ancestry (Caribbean and West Africa) to identify genetic risk factors that can be used as biomarkers to diagnose or develop therapies for TNBC patients worldwide.

Recognition/Reconnaissance

YWCA Hamilton – Woman of Distinction Award 2014

Hamilton, ON

Scientific Achievement Award 2006 | Professional

Barbados American Cancer Association, New York, NY

Professional Achievement Award 2005 | Professional

John C. Holland Black History Month Award, Hamilton, ON

Ontario Premier’s Research Excellence Award (PREA) 2001-2006 | Professional

Ministry of Economic Development and Trade, Toronto, ON

Outstanding Community Service Award 2011

The Afro-Canadian Caribbean Association of Hamilton & District Inc., ON

Nominee, President’s Award of Excellence for Graduate Supervision 2013 | Professional

McMaster University

Gold Crown of Merit for Cancer Research 2009 | Professional

Barbados National Honor, Barbados

Gordon and Jean Southam Fellowship 2014 | Professional

Association of Commonwealth Universities (ACU) Titular Fellowship, UK

Honorary Inductee International Golden Key Society 2013 | Professional

McMaster University

Errol Walton Barrow Award of Excellence 2009

Barbados Ball Canada Aid, Toronto, ON

Collaborative Conference Community Service Award 2008

Collaborative Conference of Barbadian Associations, Barbados

African Canadian Achievement Award of Excellence in Science 2008 | Professional

African Canadian Achievement Awards of Excellence, Toronto, ON

Black Arts and Innovation Expo Trailblazer Award 2016 | Professional

Excelovate and First Book Canada, Toronto, ON

17th Annual Black History Month Celebration- Actions Speak Louder than Words 2011

Toronto Police Service, Toronto, ON

AACR Minority Scholar in Cancer Research Travel Award 2004, 2005 | Professional

American Association for Cancer Research, Orlando, FL

Additional Titles and Affiliations

Member, American Association for Cancer Research (AACR)

Member, American Society for Cell Biology (ASCB)

Member, American Society for Microbiology

Member, Canadian Society for Molecular Biosciences

Co-founder, Academic Women's Success and Mentorship (AWSM) Lecture Series

Associate Member, Dept. of Oncology, McMaster University

Associate Member, Farncombe Family Digestive Health Research Institute, McMaster University

Past Talks

Think Beyond Love Pink Breast Cancer Awareness

Think Beyond Love Pink Breast Cancer Awareness Campaign

G98.7 FM, The Way We Groove, October 30, 2016

Think Beyond Love Pink Breast Cancer Awareness

Think Beyond Love Pink Breast Cancer Awareness Interview

ROGERS TV Daytime, Durham, Ontario, November 1, 2016

Research Grants

The bimodal transcriptional repressor Kaiso: mechanisms of gene regulation.

Organization: CIHR (Operating)

Details:

2004-2007

The catenin p120ctn as an importin for the transcription factor Kaiso: novel regulators of cell adhesion and tumourigenesis?

Organization: DOD IDEA Award (Operating)

Details:

2002-2005

POZ-ZF transcription factors in cell adhesion and development.

Organization: NSERC

Details:

2010-2015

POZ-ZF transcription factors in signaling and development.

Organization: NSERC (Operating)

Details:

2015-2020

Role of Kaiso in HIF-1α expression and function in hypoxia and tumorigenesis.

Organization: JCCF (Operating)

Details:

2011-2012

Roles of the bimodal transcription repressor Kaiso in cell proliferation & Wnt signaling.

Organization: CIHR (Operating)

Details:

2007-2012

Identification of a TNBC Signature in a Unique Cohort of Women of African Ancestry (WAA)

Organization: JHCCF (Operating)

Details:

2014-2015

Identification of unique triple negative breast cancer (TNBC) biomarkers in Women of African Ancestry (WAA)

Organization: CBCF

Details:

2015-2018

Defining the role of Kaiso, a POZ-zinc finger transcription factor and p120ctn- binding protein in cadherin-mediated cell adhesion and signalling.

Organization: CIHR (Operating)

Details:

2000-2003

Expertise

  • Women in Science and Engineering
  • Kaiso and transcription factors
  • Colon Cancer Research
  • Developmental Biology
  • Cell & Molecular Biology
  • Cadherin-mediated cell adhesion
  • Breast Cancer Research

Education/Éducation

  • University of British Columbia
    Microbiology
    Ph.D., 1993
  • Queen's University
    Life Sciences
    B.Sc. Hons, 1987